DIAGNOSTIC CRITERIA FOR NF1

Two or more of the following:

  1. Six or more café-au-lait spots 1.5 cm or larger in post-pubertal individuals, 0.5 cm or larger in pre-pubertal individuals
  2. Two or more neurofibromas of any type or one or more plexiform neurofibroma
  3. Freckling in the axilla or groin
  4. Optic glioma (tumor of the optic pathway)
  5. Two or more Lisch nodules (benign iris hamartomas)
  6. A distinctive bony lesion: dysplasia of the sphenoid bone or dysplasia or thinning of long bone cortex
  7. A first-degree relative with NF1

Effects of NF-1

Neurofibromatosis type 1 (NF-1) is an autosomal (A chromosome that is not a sex chromosome) dominant genetic disorder that causes tumors to grow on the covering of the nerves anywhere in the body at any time. The disorder affects 1 in 2,500 males and females of all races and ethnic groups. The NF-1 gene is located on chromosome 17.



 Complications of nf1